| SS Lazio vs. US Lecce | 11-23-2025
Sunday
TBD | Stadio Olimpico - Rome in Borgata Ottavia, Italy | View Tickets |
| US Lecce vs. Torino FC | 11-30-2025
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| US Cremonese vs. US Lecce | 12-7-2025
Sunday
TBD | Stadio Giovanni Zini in Cava Tigozzi, Italy | View Tickets |
| US Lecce vs. Pisa SC | 12-14-2025
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| US Lecce vs. Como 1907 | 12-28-2025
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Juventus FC vs. US Lecce | 1-3-2026
Saturday
TBD | Allianz Stadium in Torino, Italy | View Tickets |
| US Lecce vs. AS Roma | 1-6-2026
Tuesday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| US Lecce vs. Parma FC | 1-11-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| FC Inter Milan vs. US Lecce | 1-14-2026
Wednesday
TBD | San Siro in Milan, Italy | View Tickets |
| AC Milan vs. US Lecce | 1-18-2026
Sunday
TBD | San Siro in Milan, Italy | View Tickets |
| US Lecce vs. SS Lazio | 1-25-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Torino FC vs. US Lecce | 2-1-2026
Sunday
TBD | Stadio Olimpico di Torino in Torino, Italy | View Tickets |
| US Lecce vs. Udinese Calcio | 2-8-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Cagliari Calcio vs. US Lecce | 2-15-2026
Sunday
TBD | Sardegna Arena in Lazzaretto, Italy | View Tickets |
| US Lecce vs. FC Inter Milan | 2-22-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Como 1907 vs. US Lecce | 3-1-2026
Sunday
TBD | Stadio Giuseppe Sinigaglia in Breccia, Italy | View Tickets |
| US Lecce vs. US Cremonese | 3-8-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| SSC Napoli vs. US Lecce | 3-15-2026
Sunday
TBD | Stadio Diego Armando Maradona in Agnano, Italy | View Tickets |
| AS Roma vs. US Lecce | 3-22-2026
Sunday
TBD | Stadio Olimpico - Rome in Borgata Ottavia, Italy | View Tickets |
| US Lecce vs. Atalanta BC | 4-4-2026
Saturday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Bologna FC vs. US Lecce | 4-12-2026
Sunday
TBD | Stadio Renato Dall'ara Bologna in Bologna, Italy | View Tickets |
| US Lecce vs. ACF Fiorentina | 4-19-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Hellas Verona FC vs. US Lecce | 4-26-2026
Sunday
TBD | Stadio Marcantonio Bentegodi in Verona, Italy | View Tickets |
| US Lecce vs. Genoa CFC | 5-24-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
